Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology
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چکیده
منابع مشابه
Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology.
The mechanisms by which homocysteine contributes to atherothrombosis are complex and their in vivo relevance uncertain. In this issue of the JCI, Jacovina and colleagues report a unique in vivo mechanism by which homocysteine may contribute to vascular disease (see the related article beginning on page 3384). This group had previously reported that homocysteine impairs endothelial cell surface ...
متن کاملHomocysteine and vascular disease.
For more than 20 years, moderately raised concentrations of total homocysteine (tHcy) have been associated with an increased risk of atherothrombotic vascular events but only recently has evidence mounted to suggest that the association may be causal. The association is independent of other factors, it is fairly consistent across many studies, it is strong and dose-related, and it is biological...
متن کاملHomocysteine and vascular disease.
In my experience the largest individual group of sufferers from recurrent and especially incessant pericarditis have been those without recurrent effusions who are presumed, though rarely firmly demonstrated (as here), to have an immunopathy, and especially those who are ‘steroid hooked’. Indeed, there is some evidence that corticosteroid treatment has been necessary to initiate the cycle of re...
متن کاملHomocysteine and vascular diseases.
To the Editor: The article by Doshi et al in the January 1/8, 2002, issue of Circulation,1 in which the authors suggest that folic acid improves endothelial function by a mechanism largely independent of homocysteine (Hcy), prompted us to report our data on plasma Hcy levels before and after intravenous prostaglandin (PG) E1 -cyclodextrin in patients with systemic sclerosis. Ten patients with s...
متن کاملThe pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease.
Accumulating evidence suggests that homocysteine (Hcy) metabolite, the thioester Hcy-thiolactone, plays an important role in atherothrombosis. Hcy-thiolactone is a product of an error-editing reaction in protein biosynthesis which forms when Hcy is mistakenly selected by methionyl-tRNA synthetase. The thioester chemistry of Hcy-thiolactone underlies its ability to from isopeptide bonds with pro...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2009
ISSN: 0021-9738
DOI: 10.1172/jci40924